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PhytoSolve ADEK®: Four Lipophilic Vitamins in One Water-Soluble Formulation

Lipophilic Vitamins – A, D3, E, and K2

The four lipophilic vitamins A, D, E, and K are essential nutrients involved in numerous processes in the human body.

 Figure 1: Selected examples of 14 EFSA approved health claims.

PhytoSolve® Technology

The PhytoSolve® delivery technology enhances the uptake of lipophilic nutrients in a natural way. Fat-soluble substances, like the four lipophilic vitamins A, D, E and K, require a carrier to be effectively absorbed. Due to their amphiphilic properties, phospholipids can enclose fat droplets in the form of an emulsion. The performance of the PhytoSolve® technology could be shown in an in vivo study with vitamin E.

PhytoSolve® ADEK

The unique formulation PhytoSolve® ADEK stands out from typical ADEK products owing to its excellent performance and high customer convenience. It enables a homogeneous distribution of the four lipophilic vitamins in an easy to dose but still small volume. PhytoSolve® ADEK can be mixed in any ratio with water, juice, dairy products, and many more.

Phosphatidylcholine – Natural Support for a Healthy Liver

Fig. 1: Fatty liver disease is characterized by an increasing storage of fat in hepatocytes.

The Liver – Central Organ of Lipid Metabolism

A healthy liver is essential for a well-functioning fat metabolism.
A disturbance can lead to the accumulation of fats and result in fatty liver disease. Especially the non-alcoholic form (NAFLD) is very common in industrial countries due to the Western Style Diet and a lack of physical activity. The prevalence for NAFLD is increasing but, fortunately, the storage of fat is reversible. Therefore, choosing nutrients with hepatoprotective properties becomes more and more important.

The Importance of Phosphatidylcholine

Dietary and supplemented PC supports liver function in a natural way by regulating the fat metabolisms. In addition, polyunsaturated phospholipids (PPL) are very popular for liver protection. In several clinical studies their antioxidative and anti-inflammatory properties could be shown.

PC is also a safe and natural source of the vitamin-like substance choline. The EFSA-approved health claims illustrate the importance of the nutrient.

Lipoid offers a wide range of products enriched in polyunsaturated phosphatidylcholine. Various forms of application, like capsules or innovative liquid solutions, are possible. Due to the emulsifying properties of phospholipids the formulations are mixable with any kind of beverages. To find a suitable application for liver protecting PC just ask for our support and guidance.

PPL with high phosphatidylcholine content are the natural solution for a healthy liver.

PhytoSolve® Astaxanthin – Boosting the Performance of Natural Supplements

The most important natural source of astaxanthin is the alga Haematococcus pluvialis.

Astaxanthin – Nature’s Powerful Antioxidant

Astaxanthin is a powerful antioxidant that is naturally produced by aquatic organisms like algae. In comparison to other antioxidant nutrients, it exhibits higher capacity to scavenge reactive oxygen species (ROS).

During vigorous physical exercise, ROS are associated with soreness, fatigue, and muscle damage. Intake of astaxanthin contributes to higher endurance, reduced muscle soreness and faster recovery, making it an ideal supplement for sports nutrition.

PhytoSolve® Astaxanthin

Lipophilic nutrients like astaxanthin require solubilization to be absorbed in the human body and exert their beneficial effects. In PhytoSolve®, highly purified phospholipids enclose small oil droplets, forming an emulsion. This vehicle effectively enhances the uptake of lipophilic nutrients in a natural way.

Moreover, the formulation contains glycerol and medium-chain triglycerides (MCT). Both ingredients offer additional benefits for sports nutrition. Glycerol is used for pre-exercise hyperhydration to minimize the risk of dehydration. MCT can be used as energy source due to their rapid metabolism.

PhytoSolve® Astaxanthin is a self-preserving formulation, can be mixed with any kind of beverage, and has a very pleasant taste and smooth mouthfeel.

PhytoSolve® Astaxanthin is the smart way to formulate astaxanthin.

Schematic depiction of an emulsion droplet and its components.

LIPOID Liposome Basic: Pre-formulated High-quality Liposomes

The Basics of Liposomes

LIPOID Liposome Basic is a high-quality pre-formulated concentrate that can be combined with your nutrients of choice. The liposomes are made up of 100 % natural phospholipids which self-organize in water as bilayer structures due to their amphiphilic properties. Liposomes can help to improve the bioavailability, the stability, and the digestibility of active ingredients.

Fig. 1: Schematic diagram of phospholipids and a liposome

Why Quality Makes the Difference

We choose only natural and well selected raw materials for our formulations by meeting the highest quality standards. LIPOID Liposome Basic is self-preserving and therefore free of preservatives and ethanol. Due to its small and uniform particle size LIPOID Liposome Basic has a transparent
appearance and a great stability. The pleasant taste makes all the difference.

Versatile Applications of Liposome Basic

LIPOID Liposome Basic can be mixed with a wide range of hydrophilic nutrients without the use of expensive technical equipment. It can be utilized pure or diluted and is compatible with many types of
applicators.

The PhytoSolve®-Technology: PhytoSolve® C, PhytoSolve® Lutein D3, PhytoSolve® Omega D3: Unleashing their Full Potential with Natural Phospholipids

Boosting the Immune System

A healthy immune system contributes to overall health. It is an efficient integrated network of cellular elements and immune modulators to prevent certain diseases. Several natural nutrients are well known for supporting the immune system in various ways. These so-called immunostimulants comprise e.g. Vitamin C, Vitamin D3, and carotenoids like Lutein. They can be used as part of integrative, complementary, and preventive measures. Unfortunately, many of the immunostimulants do not have optimal properties to get absorbed effectively after oral intake. This can be greatly improved by using certain delivery technologies and excipients.

Natural Phospholipids

Key excipients to achieve this goal are natural phospholipids. Phospholipids are amphiphilic molecules and appear as part of the membrane of every living cell. Non-GMO plant-derived phospholipids are suitable to generate lipid globules like emulsion droplets and liposomes. Lipophilic nutrients are solubilized and/or emulsified, whereas hydrophilic nutrients can be encapsulated in the lipid globules. In addition, phospholipids act as a source of essential fatty acids and may protect the stomach from acidic substances. PhytoSolve® from Lipoid is a unique and natural technology to formulate lipophilic as well as hydrophilic nutrients.

PhytoSolve® C, PhytoSolve® Lutein D3, PhytoSolve® Omega D3:

These types of natural products are self-preserving and therefore free of preservatives, can be mixed with other dietetic products, and exhibit an excellent shelf life. They show a very pleasant taste and a smooth mouthfeel.

PHOSAL® H 50: Liquid Phospholipids Derived from Sunflower

The Natural All-Rounder

Lipoid’s PHOSAL® H 50 is a liquid formulation of purified phosphatidylcholine (PC) and oil from 100 % sunflower. This unique, pure and natural liquid formulation can serve as a solubilizer for lipophilic actives and can help to disperse lipid phases into aqueous systems by forming emulsion droplets.

In addition, the natural unsaturated phospholipids show various health benefits, including improving fat digestion, and are beneficial for colon and liver health. Moreover, the PC serves as the main natural dietary source of choline.

Increased Bioavailability

Phosphatidylcholine, the major phospholipid of bile, contributes physiologically to the digestion and absorption of fats and lipophilic nutrients. 

During digestion, PC together with bile salts emulsifies these fatty components into an emulsion of small fat droplets. This leads to a larger surface area of the oil phase and therefore to a much better absorption and enhanced bioavailability of the oil and components dissolved therein.

Schematic illustration of emulsion-forming properties by PHOSAL® formulations.

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PhytoSolve® C: Immune Health Booster that Unleashes Vitamin C’s Full Potential with Natural Phospholipids

Boosting the Immune System

A healthy immune system contributes to overall health. It is an efficient integrated network of cellular elements and immune modulators to prevent certain diseases. Several natural micronutrients, especially Vitamin C, are used for supporting the immune system. However, to unfold its full potential, to get high oral dosing and optimal absorption, Vitamin C needs the aid of functional formulations and excipients.

Purified and Plant-Derived Phospholipids

Key excipients to achieve optimal absorption are phospholipids. Phospholipids, from non-GMO soybean, can be used to generate tiny lecithin globules like emulsions and liposomes.PhytoSolve® is a proprietary and natural technology of Lipoid GmbH, with globules containing phospholipids as the main component. Micronutrients can be mixed with and/or encapsulated within these globules. In addition, phospholipids act as a source of essential fatty acids and may protect the stomach from acidic substances like Vitamin C.

PhytoSolve® C:

PhytoSolve® C is a natural product and contains a high concentration of Vitamin C. It is self-preserving and can be applied in various dosage forms, e.g. as sticks, sachets, shots, dispensing devices, or beverages.

Liposomes and Emulsions: Innovative Encapsulation Systems for Bioavailability Enhancement

Phospholipids from Lipoid are the ideal natural choice for the development of innovative products with numerous advantages.

Firstly, they can naturally improve the delivery and bioavailability of nutrients. An example of the enhancement of bioavailability by liposomal formulations is vitamin C. The superior delivery of liposomal encapsulated vitamin C could be shown in a study, where the oral delivery of the vitamin, (encapsulated with phospholipids), resulted in higher circulating levels – compared to pure vitamin C.

Secondly, formulations with phospholipids protect labile compounds from premature degradation in the gastrointestinal tract and therefore help to maintain the health benefits of sensitive ingredients. In pharmaceutical applications, the combination of nonsteroidal anti-inflammatory drugs with phospholipids helps to attenuate side effects related to gastrointestinal irritation. Likewise, formulations with phospholipids contribute to the maintenance of the gastrointestinal mucosa.

Thirdly, the major phospholipid phosphatidylcholine (naturally present in cell membranes of humans, animals, and plants) is also the natural source of the vitamin-like nutrient choline. Therefore, liposomal formulations with phospholipids provide the human body with choline and essential fatty acids, providing several additional benefits.

Depiction of phospholipids in an aqueous environment, an emulsion (phospholipid monolayer encapsulation of lipophilic ingredients), and a liposome (phospholipid bilayer encapsulation of hydrophilic ingredients).

Formulations with Phospholipids – Diverse Possibilities, Numerous Advantages

PHOSAL® Curcumin: The Superior Formulation for Bioavailable Curcumin

PHOSAL® Curcumin – The Natural Bioavailable Choice

PHOSAL® Curcumin is a liquid formulation of curcumin extract, purified phosphatidylcholine (PC) from sunflower lecithin, and plant oil. Curcuminoids are almost insoluble in water. Phosphatidylcholine with its combination of hydrophilic and lipophilic properties can disperse fat-soluble nutrients in an aqueous environment. PC is an important part of the micelles naturally formed during digestion and enhances the uptake of curcuminoids in the intestine.

Moreover, the formation of micelles protects sensitive components from degradation in the gastrointestinal tract [2], so that the curcuminoids can exert their full potential. The improvement of bioavailability of curcuminoids by formulation with natural phosphatidylcholine from sunflower and without any chemical additives was verified in an in vitro study.

PHOSAL® Curcumin contains about 7 % curcuminoids and approximately 50 % sunflower phosphatidylcholine. Phosphatidylcholine is the natural form of the vitamin-like substance choline that is related to different health claims by the EFSA.

Curcuminoids and Phosphatidylcholine – The Synergistic Combination

Curcuminoids and phosphatidylcholine (Fig. 2) have many health benefits. The combination of both sub-stances could lead to synergistic effects, for example against inflammatory, liver, or heart diseases.

Glycerophosphocholine (GPC): The PRO-Phospholipid with Natural Power to Reinforce Mind and Body

Glycerophosphocholine (GPC) also known as Alpha-Glycerophosphocholine is a substance derived from lecithin of vegetable sources.

We call it a “PRO” phospholipid because it is not a phospholipid, but a phospholipid-derived substance due to its lack of lipophilic fatty acids. It is a multifunctional nutrient present in all mammalian cells.

After oral consumption, LIPOID GPC-PRO is rapidly absorbed because of its high hydrophilicity. It is an acetylcholine (ACh) precursor,  which has a promising potential for the treatment of cholinergic dysfunctions.

LIPOID GPC-PRO passes easily through the blood-brain barrier providing a source of choline for ACh and phosphatidylcholine biosynthesis. The optimal phospholipid and acetylcholine levels promote cognitive, mental, and cerebrovascular health. Furthermore, a balanced GPC along with ACh concentration promotes physiological processes and body power.

ACh is involved in muscle contraction, as it is the major neurotransmitter regulating the physiological response to exercise. It can be assumed that since all muscle movements are related to contraction, and contraction is related to available cellular ACh concentration, maximizing ACh levels should optimize muscular performances. In comparison to other common cholinergic precursors, LIPOID GPC-PRO raises blood and brain choline levels safely and more efficiently. Cytidine 5-diphosphocholine or citicoline is one different choline source. However, the higher hydrophilicity and deviating roles in physiological pathways make the application of LIPOID GPC-PRO more favorable and effective. Numerous research studies explain the multifunctional benefits of GPC and suggest that oral supplementation plays a significant role in enhancing neurological function, physical performance, and memory.