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PHOSAL® Curcumin: The Superior Formulation for Bioavailable Curcumin

PHOSAL® Curcumin – The Natural Bioavailable Choice

PHOSAL® Curcumin is a liquid formulation of curcumin extract, purified phosphatidylcholine (PC) from sunflower lecithin, and plant oil. Curcuminoids are almost insoluble in water. Phosphatidylcholine with its combination of hydrophilic and lipophilic properties can disperse fat-soluble nutrients in an aqueous environment. PC is an important part of the micelles naturally formed during digestion and enhances the uptake of curcuminoids in the intestine.

Moreover, the formation of micelles protects sensitive components from degradation in the gastrointestinal tract [2], so that the curcuminoids can exert their full potential. The improvement of bioavailability of curcuminoids by formulation with natural phosphatidylcholine from sunflower and without any chemical additives was verified in an in vitro study.

PHOSAL® Curcumin contains about 7 % curcuminoids and approximately 50 % sunflower phosphatidylcholine. Phosphatidylcholine is the natural form of the vitamin-like substance choline that is related to different health claims by the EFSA.

Curcuminoids and Phosphatidylcholine – The Synergistic Combination

Curcuminoids and phosphatidylcholine (Fig. 2) have many health benefits. The combination of both sub-stances could lead to synergistic effects, for example against inflammatory, liver, or heart diseases.

Glycerophosphocholine (GPC): The PRO-Phospholipid with Natural Power to Reinforce Mind and Body

Glycerophosphocholine (GPC) also known as Alpha-Glycerophosphocholine is a substance derived from lecithin of vegetable sources.

We call it a “PRO” phospholipid because it is not a phospholipid, but a phospholipid-derived substance due to its lack of lipophilic fatty acids. It is a multifunctional nutrient present in all mammalian cells.

After oral consumption, LIPOID GPC-PRO is rapidly absorbed because of its high hydrophilicity. It is an acetylcholine (ACh) precursor,  which has a promising potential for the treatment of cholinergic dysfunctions.

LIPOID GPC-PRO passes easily through the blood-brain barrier providing a source of choline for ACh and phosphatidylcholine biosynthesis. The optimal phospholipid and acetylcholine levels promote cognitive, mental, and cerebrovascular health. Furthermore, a balanced GPC along with ACh concentration promotes physiological processes and body power.

ACh is involved in muscle contraction, as it is the major neurotransmitter regulating the physiological response to exercise. It can be assumed that since all muscle movements are related to contraction, and contraction is related to available cellular ACh concentration, maximizing ACh levels should optimize muscular performances. In comparison to other common cholinergic precursors, LIPOID GPC-PRO raises blood and brain choline levels safely and more efficiently. Cytidine 5-diphosphocholine or citicoline is one different choline source. However, the higher hydrophilicity and deviating roles in physiological pathways make the application of LIPOID GPC-PRO more favorable and effective. Numerous research studies explain the multifunctional benefits of GPC and suggest that oral supplementation plays a significant role in enhancing neurological function, physical performance, and memory.