PRODUCTS IN ORAL APPLICATIONS<\/span><\/p>\n Phospholipids \u2013 to improve the oral absorption of active ingredients<\/span><\/p>\n<\/div><\/div><\/div><\/div><\/div> PRODUCTS IN ORAL APPLICATIONS<\/span><\/p>\n<\/div> In oral applications phospholipids aim to enhance oral uptake and bioavailability of poorly water-soluble drug substances. They can reduce irritation of the stomach or help to protect the API from degradation.<\/p>\n The phospholipids are mainly applied in emulsions, dispersions, mixed micelles, (pro) liposomes, solid dispersions, and non-aqueous phospholipid formulations. They can serve as wetting agents, emulsifiers, solubilizers, or lipid matrix forming excipients. Such formulations can be converted into dry forms such as granules, powders, and tablets by adding appropriate excipients or directly filled, e.g., into capsules, sachets, or bottles.<\/p>\n Liquid Phospholipid Formulations<\/span><\/strong> Emulsions<\/strong><\/span> (Mixed) Micelles<\/strong><\/span> Solid Dispersions<\/strong><\/span> Phospholipids as API\u2019s<\/strong><\/span> The products shown below represent a selection of our extensive product range.<\/p>\n<\/div><\/div><\/div><\/div><\/section>\n
Oral Applications<\/h1><\/div>
\nLiquid, non-aqueous concentrates of phospholipids in combination with oils or a water-miscible solvent like propylene glycol are suitable for dissolving APIs. Diluted in water, they help to disperse the API in the aqueous phase. They \u00a0may be directly filled into capsules, bottles, or sachets as dosage form.<\/p>\n
\nWhen the drug has sufficient solubility in oils, O\/W emulsions or self-emulsifying systems can be prepared with phospholipids as emulsifiers or co-emulsifiers.<\/p>\n
\n(Mixed) Micelles comprising phospholipids and bile salts mimic natural gut solubilization systems and are valued solubilizers, even for pediatric use.<\/p>\n
\nA poorly soluble API and a phospholipid, for example, spray-dried with or without polymers, form solid dispersions with the amorphous state of the drug. Upon hydration, the phospholipids act as wetting agents and solubilizers.<\/p>\n
\nPolyunsaturated\/Polyenyl Phospholipids (PPL) derived from soybean are used for the prevention and treatment of liver diseases. These phospholipids suppress the formation of detrimental Radical Oxygen Species (ROS). They are available either as soybean phospholipid raw material or as formulated liquid products.<\/p>\n<\/div><\/div><\/div><\/div><\/div>Products<\/h2><\/div><\/div><\/div><\/div><\/div>